Tracking
clonal dominance
PMD is a geometric framework for quantifying clonal dominance in integration site analysis, positioning clonal populations along a continuum from maximal evenness to monoclonality.
The PMD clonal plane
About the research
The PMD framework combines observed clonal richness and dominant-clone abundance to support interpretable comparisons of clonal composition. The research also investigates fragmented dominance arising from multiple vector integrations.
PMD: A Geometric Coordinate for Clonal Dominance in Gene and Cell Therapy
Analysis tool · proof of concept
The online analysis tool ↗ is an early proof of concept for exploring PMD on integration site data. A complete application with a more robust service will be released as soon as possible.
We do not use or keep the data you upload. The tool runs on a third-party hosting service, so please do not upload sensitive, confidential or patient-identifiable data.